The ubiquitin proteasome system (UPS) utilizes an orchestrated enzymatic cascade of E1, E2, and E3 ligases to add single or multiple ubiquitin-like molecules as post-translational modification (PTM) to proteins.Ubiquitination can alter protein functions and/or mark ubiquitinated proteins for proteasomal degradation but deubiquitinases (DUBs) can re
Abstract Disasters caused by mine water inflows significantly threaten the safety of coal mining operations.Deep mining complicates the acquisition of hydrogeological parameters, the mechanics of water inrush, and the prediction of sudden changes in mine water inflow.Traditional models and singular machine learning approaches often fail to accurate
This paper has purpose to the study of factors for motivation of the creative class to work more efficiently.The paper examines the case of IT professionals in Latvia, a significant participant in knowledge economy.IT professionals are more flexible in terms of looking for a job on the labor market all over the world, opportunities iphone 13 pro ma